Abstract
Four new prenylated flavonoids (1-4), a new stilbenoid (5), and nine known compounds were isolated from the twigs of Artocarpus rigida, collected in Indonesia. The structures of the new compounds were determined by analysis of their spectroscopic data, and the absolute configuration at C-12 of 1 and 2 and the known compounds artonin O (6), artobiloxanthone (7), and cycloartobiloxanthone (8) was determined from their CD and NMR spectroscopic data. Several of the compounds obtained were cytotoxic toward HT-29 human colon cancer cells, with the most potent being compound 2 and the known compounds 6 and 8. Of the substances obtained, compounds 1 and 7 were the most active in the NF-kappaB p50 and p65 assay, respectively.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Artocarpus / chemistry*
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Drug Screening Assays, Antitumor
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Flavonoids / chemistry
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Flavonoids / isolation & purification*
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Flavonoids / pharmacology*
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HT29 Cells
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Humans
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Indonesia
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Molecular Structure
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NF-kappa B / antagonists & inhibitors*
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NF-kappa B p50 Subunit / analysis
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Plant Stems / chemistry
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Stilbenes / chemistry
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Stilbenes / isolation & purification*
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Stilbenes / pharmacology*
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Transcription Factor RelA / analysis
Substances
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Antineoplastic Agents, Phytogenic
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Flavonoids
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NF-kappa B
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NF-kappa B p50 Subunit
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Stilbenes
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Transcription Factor RelA